The increased extensibility of pregnant myometrium
نویسندگان
چکیده
منابع مشابه
TRANSLATIONAL PHYSIOLOGY Increased cholesterol decreases uterine activity: functional effects of cholesterol alteration in pregnant rat myometrium
Smith, R. D., E. Babiychuk, K. Noble, A. Draeger, and Susan Wray. Increased cholesterol decreases uterine activity: functional effects of cholesterol alteration in pregnant rat myometrium. Am J Physiol Cell Physiol 288: C982–C988, 2005. First published December 22, 2004; doi:10.1152/ajpcell.00120.2004.—Uterine quiescence is essential for successful pregnancy. Cholesterol and triglycerides are m...
متن کاملAdenylyl cyclase isoforms in pregnant and non-pregnant human myometrium.
The precise factors involved in the transition of the relaxed pregnant uterus to the contractile state at the onset of parturition remain unclear, but it is accepted that cAMP-generating pathways contribute to uterine relaxation. We have previously reported an increased expression of the adenylyl cyclase (AC)-stimulating protein Galphas in human myometrium during gestation, with a corresponding...
متن کاملIncreased cholesterol decreases uterine activity: functional effects of cholesterol alteration in pregnant rat myometrium.
Uterine quiescence is essential for successful pregnancy. Cholesterol and triglycerides are markedly increased in pregnancy. Cholesterol is enriched in microdomains of the plasma membrane known as rafts and caveolae. Both lipid rafts and caveolae have been implicated in cellular signaling cascades. The purpose of this work was to investigate whether manipulation of cholesterol content alters ut...
متن کاملThe regulation of myosin phosphatase in pregnant human myometrium.
Myometrial smooth muscle contractility is regulated predominantly through the reversible phosphorylation of MYLs (myosin light chains), catalysed by MYLK (MYL kinase) and MYLP (MYL phosphatase) activities. MYLK is activated by Ca2+-calmodulin, and most uterotonic agonists operate through myometrial receptors that increase [Ca2+]i (intracellular Ca2+ concentration). Moreover, there is substantia...
متن کاملDifferential expression of ryanodine receptor RyR2 mRNA in the non-pregnant and pregnant human myometrium.
We describe here the expression of the ryanodine receptor isoforms RyR2 and RyR3 in human non-pregnant and pregnant (non-labouring) myometrium, and in isolated cultured myometrial cells. The mRNA encoding the RyR3 isoform was found in both non-pregnant and pregnant myometrial tissue samples; however, the mRNA for RyR2 was found only in pregnant samples. It can be speculated that the appearance ...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 1966
ISSN: 0022-3751
DOI: 10.1113/jphysiol.1966.sp007845